The film mainly parodies The Twilight Saga franchise, specifically the first film and its sequel New Moon, with character names like Edward Sullen, Becca Crane, and the town of Sporks referencing the original Twilight setting of Forks.

The parody includes pop culture jabs such as the vampires being mistaken for the Black Eyed Peas, Becca's mother having an affair with Tiger Woods, Edward being mistaken for one of the Jonas Brothers, and Edward dating Lady Gaga in Rio de Janeiro after leaving Becca.

Despite near-universal critical panning, Jenn Proske's impersonation of Kristen Stewart's Bella-like mannerisms was singled out for praise by critics such as the Tampa Bay Times and Entertainment Weekly.

The film holds a 4% approval rating on Rotten Tomatoes based on 89 reviews and an 18/100 score on Metacritic, indicating overwhelming critical dislike.

Spill.com critic Korey Coleman gave the film an unusually blunt twenty-second review consisting of him staring at the camera before saying 'Fuck you,' the site's lowest possible rating.

Rolling Stone critic Peter Travers gave the film zero out of four stars with a four-word review: 'This movie sucks more.'

The film received four Golden Raspberry Award nominations, including Worst Picture, Worst Director, Worst Screenplay, and Worst Prequel, Remake, Rip-Off or Sequel.

Despite the negative reviews, Vampires Suck grossed $80,547,866 worldwide and opened at number one at the U.S. box office on its release day.