Zombies 3 was officially announced on March 22, 2021, with filming scheduled to take place in Toronto, Canada, and at the University of Toronto Mississauga.

Matt Cornett, Kyra Tantao, and Terry Hu were announced on May 19, 2021, as playing the alien characters A-Lan, A-Li, and A-Spen, respectively.

RuPaul joined the cast as the voice of 'The Mothership,' described as a comedically passive-aggressive UFO, with the casting announced on May 20, 2022.

Production on the film began on May 31, 2021, and wrapped in July 2021, while the music video for the song 'What Is This Feeling' was shot separately in Los Angeles in September 2021.

Because Kylee Russell was pregnant during filming, her scenes as Eliza were shot only from the torso up, and her character interacted with the rest of the cast through a robot body to disguise her pregnancy.

Nielsen Media Research reported that Zombies 3 was the seventh most-streamed film in the U.S. with 332 million minutes viewed between July 11 and 17, 2022, while Whip Media's TV Time app ranked it the fourth most-streamed film that week.

On Rotten Tomatoes, the film holds a 75% approval rating from 8 critics with an average score of 6.30/10.

The film's success led to a fourth installment, Zombies 4: Dawn of the Vampires, greenlit on February 10, 2024, with production beginning in New Zealand in March 2024.