The character Vincent Van Ghoul was directly based upon and voiced by horror film icon Vincent Price.

Fred Jones and Velma Dinkley do not appear in this series; a later film explained they were away at summer camp during this time.

The series was created by Mitch Schauer, with Tom Ruegger serving as associate producer and story editor; the irreverent, fourth wall-breaking humor he brought would later resurface in his subsequent works like A Pup Named Scooby-Doo, Tiny Toon Adventures, and Animaniacs.

Tom Ruegger later admitted he was not fond of the Flim-Flam character or the other added cast members, feeling they had been included only to appease focus groups.

ABC canceled the show after only 13 episodes in March 1986, replacing it with reruns of Laff-a-Lympics, partly because the network was shifting its Saturday morning lineup to target preschoolers, a strategy that later proved to be a ratings failure since preschoolers could not operate the newly introduced people meters.

When the series was cancelled, the story was left unresolved with twelve of the thirteen ghosts recaptured but the final ghost still at large; this cliffhanger wasn't resolved until the 2019 direct-to-video film Scooby-Doo! and the Curse of the 13th Ghost, released 34 years later.

This is the last regularly running Scooby-Doo series to feature Scrappy-Doo as a main character before he was dropped from the franchise after three 1987-88 television movies.

The series was heavily profiled in the Christian fundamentalist documentary Deception of a Generation as an example of alleged occult influences in children's entertainment.

For this series Shaggy wore a redesigned outfit with a red T-shirt, baggy blue jeans, and brown shoes instead of his usual colors, a change that has never been officially explained; he would only wear this look in four more appearances over the following decades, most recently in 2001's Scooby-Doo and the Cyber Chase.