The drama is based on an original webtoon that tells the story of a male gumiho who has lived for hundreds of years trying to become human, and who accidentally has his fox beads taken by a female college student.

My Roommate is a Gumiho is the first South Korean drama produced by iQiyi, made as a joint production between China and South Korea.

Lee Hye-ri and Jang Ki-yong had previously co-starred together in the 2015 drama Schoolgirl Detectives, reuniting six years later for this series.

Lee Hye-ri and Park Kyung-hye had previously worked together on the workplace drama Miss Lee.

Kang Han-na and Kim Do-wan had previously starred together in the 2020 hit drama Start-Up before being cast as a couple in this series.

Director Nam Sung-woo and actor Jang Ki-yong had already collaborated on the 2018 OCN weekend drama Kill It before teaming up again for this series.

Creator Park Jun-hwa and writer Baek Sun-woo, together with writer Choi Bo-rim, worked together for the eleventh time on this project.

Director Nam Sung-woo and actor Kim Eung-soo previously worked together on the MBC miniseries Chief Kim (Kkondae Intern), which led to Kim Eung-soo's cameo appearance in this drama.

Kim Eung-soo and Lee Hye-ri reunited on this drama three years after having worked together on the tvN drama Miss Lee (Cheongil Jeonja Miss Lee).