The series was originally reported to have been filmed as eight episodes, but after production issues, Marvel Studios head Kevin Feige found it 'unreleasable' and much of it was ultimately reshot, resulting in a final cut of five episodes.

Maya Lopez's Indigenous heritage was reimagined for the MCU, making her a member of the Choctaw tribe in Oklahoma instead of the Blackfeet Nation as depicted in the comics, since the writers felt the comics' visuals were an inauthentic 'hodgepodge' of imagery.

Alaqua Cox, who plays Maya Lopez, is deaf and an amputee, and her real-life cousin Darnell Besaw portrays a young version of the character in flashbacks.

Devery Jacobs, who plays Bonnie, had previously voiced the character Kahhori in the second season of What If...?, which she noted was a coincidence since the two characters are unrelated despite both being in Marvel Studios projects.

Vincent D'Onofrio wore a fat suit to portray Wilson Fisk in Echo, having previously gained 40 pounds (18 kg) for the role in the Daredevil Netflix series, and found that modern fat suit technology gave a more realistic look while being lighter to wear.

A traditional Choctaw blessing ceremony was performed before filming began, and department heads traveled to the Choctaw Nation in Oklahoma to learn the language and culture and attend a powwow, later using reference photos to find similar-looking locations around Atlanta, Georgia.

Many crew members took American Sign Language classes so that close-up shots could include actors signing, and ASL consultant Douglas Ridloff adjusted translations for each character, incorporating Plains Indian Sign Language and other Indigenous sign languages predating colonization.

Unlike prior MCU Disney+ series that typically featured original scores, Echo's soundtrack heavily featured pre-existing vocal songs, including 'Burning' by Yeah Yeah Yeahs over the main titles; composer Dave Porter took over scoring duties after Mato Wayuhi departed the project.

Echo was the first Marvel Studios television series to receive a TV-MA rating and the first to debut on Hulu, and it was also the first Marvel series to release all its episodes at once rather than weekly.

A Choctaw language dub of the series became available on Disney+ on November 1, 2024, with consultant Terry Billy working to translate English into 'everyday' Choctaw when direct translation wasn't possible.