In a 1975 interview with radio historian Chuck Schaden, actor Alan Reed revealed that Hanna-Barbera was developing a segment about Fred and Barney working as Bedrock policemen, which would later become the 'Bedrock Cops' segment.

Alan Reed, the original voice of Fred Flintstone, died on June 14, 1977 while the 'Bedrock Cops' segment was still in development, and he was replaced by Henry Corden.

The 'Captain Caveman' segment served as a prequel to Captain Caveman and the Teen Angels, featuring the character's editor-in-chief Lou Granite, a parody of Lou Grant, and giving Captain Caveman a secret identity disguise (glasses and tie) reminiscent of Superman's Clark Kent.

The 'Pebbles, Dino and Bamm-Bamm' segment reused characters like Penny, Wiggy and Moonrock from the earlier The Pebbles and Bamm-Bamm Show, aging Pebbles and Bamm-Bamm down slightly from their prior appearances, and followed the 'mystery-solving teens and a pet' format popularized by Scooby-Doo.

The series incorporated pre-existing Hanna-Barbera characters from other shows, including the Shmoo from Al Capp's The New Shmoo (1979) and Captain Caveman from his own 1977 ABC series.

The 'Dino and the Cavemouse' segment, a Tom and Jerry-style chase cartoon, was story edited and had its title character developed by legendary animation director Tex Avery, marking the last project he worked on before his death.

After its original run, the series was repackaged as The Flintstone Funnies from 1982 to 1984, consisting of reruns of the six segments, and it stands as the final incarnation of The Flintstones to premiere on NBC.