Screenwriter Jeong Seo-kyung, known for films like Oldboy-related works and The Handmaiden, revealed in a November 2021 interview that she was adapting Little Women into a Korean drama with the director of Vincenzo, and mentioned that she had read and loved the original Little Women novel as a child.

Jeong Seo-kyung confirmed early on that Kim Go-eun and Nam Ji-hyun would play the leading sisters, while Wi Ha-joon, known for Squid Game, would be the male lead.

Filming took place from June to July 2022, with several locations shot in Singapore.

On March 3, 2022, actor Wi Ha-joon tested positive for COVID-19 during production and was expected to be released from quarantine on the 8th, which was later confirmed.

Little Women holds a 100% approval rating on Rotten Tomatoes based on 5 reviews, with an average rating of 8.5/10.

In September 2022, the production staff and poster designer Propaganda issued public apologies after the drama's poster was found to closely resemble a 2016 exhibition poster for a Japanese cosmetics brand.

On October 3, 2022, Vietnam's Authority of Broadcasting and Electronic Information requested the removal of Little Women from Vietnamese Netflix, accusing episodes 3 and 8 of distorting Vietnam War history and glorifying South Korea's wartime involvement; the drama staff apologized on October 7, 2022.