It was reported on March 17, 2021 that singer-actor Rain would make his acting comeback with Ghost Doctor, directed by Bu Seong-cheol and written by Kim Seon-sun, produced by Bone Factory.

Rain's role in Ghost Doctor marked his first drama appearance since the 2019 series Welcome 2 Life.

The full cast lineup for the series was officially confirmed on November 8, 2021.

Actress Son Na-eun shared a behind-the-scenes photo from the filming location on November 2, 2021, ahead of the show's premiere.

Filming for the 16-episode series was reported to have wrapped on February 6, 2022, shortly before the finale aired.

At the 2022 Korea Drama Awards, actor Kim Bum won the award for Best Actor.

The character Go Seung-tak became known in-universe for a legendary interview anecdote, answering the standard 'why medicine' question with blunt lines like 'because my grandfather told me to' and 'because my mom told me to.'