Felicia Day wrote The Guild's pilot script based on her personal experience with a World of Warcraft addiction, but kept the plot generic to avoid copyright issues and appeal to a wider MMORPG fan audience.

Day created the diverse cast of characters specifically to reflect real-life gamers and subvert the stereotypical depiction of gamers as lonely men.

Day wrote roles specifically for Sandeep Parikh and Jeff Lewis, whom she already knew from the Empty Stage Comedy Theatre in Los Angeles, while the rest of the cast was found through auditions.

The first three episodes of the series were filmed in just two and a half days, after which production ran out of money.

After running out of funds, the production financed episodes four and five almost entirely through donations solicited via PayPal.

After Microsoft's business model changed following season five, Felicia Day chose to keep ownership of the series and moved episode premieres to her own YouTube channel, Geek & Sundry.

The actress playing Bladezz's little sister Dena, Tara Caso, is the real-life sister of Vincent Caso, who plays Bladezz.

Joss Whedon credited The Guild as one of the inspirations for Dr. Horrible's Sing-Along Blog, which also starred Felicia Day.

A costume from the series was accessioned into the collection of the National Museum of American History at the Smithsonian Institution in Washington, D.C.

The Guild had over 69 million upload views on YouTube as of September 2011 and was named one of 'The Net's Best Serial Shows' by Rolling Stone in February 2009.

Felicia Day revealed at MCM Comic Con London in October 2023 that she was developing a stage musical adaptation of The Guild, which had its first staged reading at Dynasty Typewriter in February 2025 with Day reprising her role as Codex.