Forest Whitaker took on the role of narrator and on-screen host, a position originally held by Rod Serling in the 1959 series.

Bill Mumy reprised his role as Anthony from the original 1961 episode 'It's a Good Life' in the sequel episode 'It's Still a Good Life', 41 years later, with his real-life daughter Liliana Mumy playing Anthony's daughter.

Cloris Leachman also returned in 'It's Still a Good Life' to reprise her role as Anthony's mother from the original series.

Bill Mumy went on to work as a screenwriter for other episodes of this 2002 revival, in addition to reprising his acting role.

Several guest stars, including Christopher McDonald, Wallace Langham, Xander Berkeley, and Lukas Haas, had also previously guest starred in the 1980s revival of The Twilight Zone.

The first half of the season used an opening title sequence featuring images of Rod Serling with a creepier musical arrangement, which was later replaced by a more iconic rock-themed opening scored by Jonathan Davis, singer of the band Korn, with the Serling imagery removed.

The episode 'The Monsters Are on Maple Street' is a modernized remake of the classic 1960 episode 'The Monsters Are Due on Maple Street', replacing the original's Cold War allegory about alien invasion paranoia with a post-9/11 theme about terrorism.

The episode 'Eye of the Beholder', starring Molly Sims, is a remake of a famous episode from the original 1959 Twilight Zone series.