The fictional town of Sheltered Shrubs is based on Larchmont, New York, where series creator Emily Kapnek moved during junior high; she said the town became 'sort of the basis for this show'.

Unlike most animated shows of the era, characters' wardrobes rotated and evolved constantly, changing clothes every episode and sometimes within the same episode, mimicking live-action sitcoms rather than following the industry-standard practice of a single default outfit used by other Klasky Csupo shows like Rugrats and Rocket Power.

Hoodsey's constant purple hoodie and shorts were written as a satire of traditional one-outfit cartoon characters, later subverted by revealing his closet is full of nearly identical purple hoodies, implying he actually changes clothes as often as everyone else.

The episode 'No Hope for Courtney' was rewritten to write out the character Mrs. Gordon after her voice actress, Kathleen Freeman, died before the episode was completed; the episode's ending credits played with no music as a tribute to her.

A young fan named Leandra, who had a bone marrow illness and was a Make-A-Wish patient, got her wish granted to appear on the show and voiced a character named after herself in the episode 'Butterflies are Free'.

The theme song 'I'm in Between' went through three different recorded versions: first sung by Ginger's voice actress Melissa Disney, then by Cree Summer (voice of Miranda), and finally by R&B singer Macy Gray, whose version became the most widely used and recognized.

In the original Melissa Disney version of the opening titles, character dialogue and sound effects (like Darren greeting his friends or Carl's dog-house chase) played over the animation; when the Macy Gray version replaced it, the audio was removed but the original mouth animations were left unchanged, leaving characters silently mouthing now-absent lines.

Nickelodeon originally asked for the ending of the finale TV film 'The Wedding Frame' to be changed to something less conclusive in case more episodes were ordered, but the original, conclusive ending was ultimately kept.

In the TV film 'The Wedding Frame', the Foutleys drive past a cemetery where one tombstone reads 'ATBG' and another 'RIP', a self-aware nod to the fact that the film served as the series finale.

Several Season 3 'high school' episodes went unaired in the U.S. for years; some premiered on TeenNick's The Splat in 2016, while the last two, including 'The Wedding Frame' (previously only on a 2004 DVD) and 'Battle of the Bands', didn't premiere until CBS All Access in 2021.