Peter Scolari took over the role of inventor Wayne Szalinski, originally played by Rick Moranis in the 1989 film.

The series was filmed in Calgary, Alberta, with its main studios based at Currie Barracks, a decommissioned Canadian Forces dormitory.

The family dog Quark was played by two different dogs during the show's run: Matese in season one and Rusty in seasons two and three.

The show launched in September 1997, shortly after the direct-to-video release of Honey, We Shrunk Ourselves, the last film in the trilogy.

The Szalinskis' third child Adam, introduced in Honey, I Blew Up the Kid, is never mentioned in the series; it is only clarified in the penultimate episode, via Diane's pregnancy announcement, that the show takes place between the first film and its sequel.

Rick Moranis is referenced in one episode when Amy tells Wayne he resembles him, though Wayne has no idea who Moranis is.

After the first season, writers Ed Ferrara and Kevin Murphy departed, and Ed Naha, one of the original film's creators, joined as head writer and co-executive producer for the final two seasons.

Stuart Gordon, another creator of the original film and executive producer of Honey, I Blew Up the Kid, directed the season two episode 'Honey, Let's Trick or Treat.'

The series won Daytime Emmy Awards for Outstanding Sound Mixing in 2000 and 2001, and was nominated for Outstanding Sound Editing in 1999.

A precipitous ratings drop in the third season led Disney to end production, with the series finale airing on May 20, 2000.