The show was filmed at the CBS Studio Center in Los Angeles, California.

The illustrations and animations representing Caroline's in-show comic strip were drawn by Bonnie Timmons.

Although not officially a companion series, Caroline in the City shares a universe with Frasier, with crossovers including an early first-season episode showing Frasier characters Daphne and Niles (played by Jane Leeves and David Hyde Pierce) filmed on Frasier's actual Paramount set.

Series lead Eric Lutes also played Frasier's boss Tom Duran in two episodes of Frasier, while David Hyde Pierce appeared a second time on the show as a different character, an IRS man who dreams of being in Cats.

Frasier actors Dan Butler (Bulldog), Harriet Sansom Harris (Bebe) and Edward Hibbert (Gil) all made appearances on Caroline in the City playing different characters, with Harris and Hibbert even appearing in the same third-season episode without sharing scenes.

In the episode 'Caroline and the Folks,' Matthew Perry appeared as his Friends character Chandler Bing in a crossover, and that same night Lea Thompson appeared as Caroline Duffy in the Friends episode 'The One with the Baby on the Bus' (aired November 2, 1995).

The same crossover episode 'Caroline and the Folks' also featured Jonathan Silverman appearing as his character Jonathan Eliot from the sitcom The Single Guy.

CBS DVD released the first two seasons in Region 1 in 2008/2009, but it took a decade before the remaining two seasons were released in 2019, and even then they were missing some episodes.