The series was originally ordered under the title Breathe in February 2021 before being retitled Keep Breathing in June 2022, shortly before its premiere.

The limited series was created, written, and executive produced by Martin Gero and Brendan Gall, with production handled by Warner Bros. Television.

Melissa Barrera was cast as the lead, Liv, in June 2021, before other recurring cast members like Jeff Wilbusch, Florencia Lozano, and Juan Pablo Espinosa joined the following month.

Austin Stowell joined the cast as Sam, a co-pilot, in September 2021, several months after the rest of the main cast was set.

Filming took place in Vancouver, running from June 28, 2021, to September 20, 2021.

The show received mixed reviews, holding a 56% approval rating on Rotten Tomatoes and a score of 45/100 on Metacritic, with critics praising Melissa Barrera's performance but criticizing the series when it broadened its scope.