The series marked the third collaboration between director Yoo Je-won and screenwriter Yang Hee-seung, following their previous work together on High School King of Savvy (2014) and Oh My Ghost (2015).

Filming for the series was reported to have begun in the summer of 2022 and wrapped up on February 5, 2023.

Each of the 16 episode titles refers to a mathematical concept, tying into the show's math-instructor theme.

The series' original script was published as two separate books, each covering eight episodes.

During its broadcast, Crash Course in Romance ranked first for four consecutive weeks in the Good Data Corporation's Top 10 TV Topicality Ranking for dramas, with a topicality share of 23.8%.

The drama topped OTT media service drama rankings for three consecutive weeks, including leading the Kinolights weekly integrated content ranking chart.

The flower-patterned blouse worn by Jeon Do-yeon's character Nam Haeng-seon became a fashion trend nicknamed 'Southbound fashion,' boosting sales of retro-style blouses on Korean shopping platforms Gmarket and SSG.com.

The soundtrack features classical pieces including Mozart's Concerto for Flute, Harp and Orchestra, Dvořák's Serenade for Strings, Debussy's Clair de Lune from the Suite bergamasque, Chopin's Andante spianato et grande polonaise brillante, and Schumann's Träumerei, used in key scenes such as the blind date between Chi-yeol and Hye-yeon.