The series was announced in February 2024 when creator Ryan Murphy released a teaser on Instagram, revealing that Niecy Nash, Courtney B. Vance and Lesley Manville were set to star.

On Rotten Tomatoes, 75% of 16 critics' reviews are positive, with a consensus calling it 'equal parts campy and terrifying,' while Metacritic gave it a 'mixed or average' score of 51 out of 100 based on 7 critics.

Several critics compared Grotesquerie to Ryan Murphy's American Horror Story as well as to films like Seven and Hannibal, noting its heavy sense of dread and religious symbolism.

The series debuted at No. 1 on Hulu's 'Top 15 Today' list on its first full day of release and stayed on the list for five consecutive days, appearing alongside other Ryan Murphy-produced shows like American Sports Story and Doctor Odyssey.

Streaming aggregator Reelgood ranked Grotesquerie as the eighth most-streamed TV series in the U.S. for the week of September 26 to October 2, 2024, and ninth for the week ending October 9.

The series premiere drew 343,000 viewers (P2+) with a 0.11% rating, while later episodes saw declining viewership, dropping to around 196,000–200,000 viewers by mid-to-late October.

Grotesquerie was one of 200 television series awarded the ReFrame Stamp for 2024–2025, an accolade recognizing gender-balanced hiring practices in film and television production.