The series was created by Bryan Fuller for Showtime, though the show is set in Seattle, it was actually filmed in Vancouver, British Columbia.

Bryan Fuller left the show only five episodes into the first season due to creative differences and conflicts with MGM Television over major script and storyline cuts he considered essential.

Fuller described his experience on the show as 'the worst experience of my life,' saying MGM's lack of professionalism made it 'like being at war' as they constantly tried to strong-arm him.

Actress Rebecca Gayheart, who played reaper Betty Rhomer, departed the series after only the fifth episode.

The undead appearance of lead character George was portrayed by Laura Boddington in the TV series, while Jennifer Rae Westley took over the role for the direct-to-DVD film.

In the direct-to-DVD sequel film 'Life After Death,' Mandy Patinkin's character Rube does not appear (reportedly having moved on), and a new reaper leader named Cameron Kane, played by Henry Ian Cusick, was introduced instead; Daisy was also recast, played by Sarah Wynter.

La-La Land Records released a soundtrack album of the series' original score, composed by Stewart Copeland, on May 25, 2010, as a limited edition of only 3,000 units.

The series premiere drew 1.11 million viewers, a ratings record for a Showtime series premiere that stood until Shameless surpassed it seven years later.

On Rotten Tomatoes, the first season holds a 69% approval rating while the second season jumped to a 100% approval rating, reflecting a notable improvement in critical reception.