In 2020, Nobuhiro Takenaka, representative of CygamesPictures, proposed a concept to screenwriter Shigeru Murakoshi: "An alien visits a hotel on Earth run by robots after humanity has disappeared." This concept became the starting point of the project.

Director Kana Shuto was drawn to the original character design and concept by Izumi Takemoto and participated in the production. After reading the outlines for all 12 episodes, she felt the story was well-crafted and interesting.

The protagonist Yachiyo was initially designed as a robot that was "emotionless" and "made calm judgments," but after researching advances in AI and robotics technology, the character was changed to have a more human-like thought pattern. Nobuhiro Takenaka further proposed adding an "unknown expansion feature" to make the character more appealing.

The space scene in Episode 7 was influenced by the film Gravity, the reinforced suit for Ponko in Episode 8 was influenced by Aliens, the scene of breaking down a door with an axe in Episode 10 references The Shining, and the subplot of hiding a corpse references Harry and the Hendersons.

The Environment Check Robot was created with inspiration from the robot "TARS" that appears in the film Interstellar.

Ginza was chosen as the setting for Hotel Galaxia because it has a tradition dating back to the Edo period, has been influenced by Western culture, and is located near Tokyo Bay. The production team also wanted to depict the rise in sea level after the apocalypse. The hotel's exterior is modeled after Ginza Wako.

When the story's setting was first conceived, a clock tower was considered as the location of the hotel, but ultimately a building was chosen as a symbolic structure representing "Ginza-ness," and the front of the Kabuki-za was adopted as a model for the hotel's hot spring.

The American newspaper The New York Times selected Episode 11 as one of the "Best Television Episodes of 2025," and in Anime News Network's reader poll it was selected as "the most underrated anime."

Kinoko Nasu, co-founder of Type-Moon, evaluated this work as one of the representative anime of this century, not just 2025, and Takashi Takeuchi spoke of laughing hard while crying, indicating it received high praise from industry figures.

The work became a finalist for the 46th Japan Science Fiction Grand Prize, and in 2026 it won the 57th Nebula Award Media Division. At the same time, the manga adaptation Apocalypse Hotel Puspusu also won the Nebula Award Comic Division, resulting in a double award for both anime and manga.