9-1-1: Nashville is the second spin-off of the 9-1-1 franchise, following 9-1-1: Lone Star, which concluded in February 2025.

ABC announced a straight-to-series order for 9-1-1: Nashville in February 2025, right after 9-1-1: Lone Star wrapped up.

The decision to set the series in Nashville was influenced by the city's distinctive musical culture and scenic setting.

Chris O'Donnell was announced as the star of the series on March 17, 2025, followed by Jessica Capshaw the next month, then LeAnn Rimes and Kimberly Williams-Paisley in May 2025.

Hailey Kilgore, Michael Provost, Juani Feliz and Hunter McVey were announced as series regulars in June 2025, with Gregory Alan Williams, MacKenzie Porter, and Tim Matheson joining in recurring roles in August 2025.

Ryan Phillippe joined the cast as a series regular for the second season on April 20, 2026.

The series features crossover guest appearances from the original 9-1-1 show, with Oliver Stark and Ryan Guzman reprising their roles as Evan 'Buck' Buckley and Edmundo 'Eddie' Diaz.

The premiere episode drew 12.4 million total viewers across all platforms after seven days, a 231% increase from its same-day audience, and ranked as ABC's second-highest drama premiere on streaming after seven days, behind High Potential.