Studio&New announced on August 18, 2025 that it had signed a co-production agreement with Artist Company to co-produce three series, including Nice to Not Meet You.

The script reading for the series was completed and filming began around March 21, 2025.

Director Kim Ga-ram previously worked on Nevertheless (2021) and Good Partner (2024), while writer Jeong Yeo-rang previously wrote Five Enough (2016) and Doctor Cha (2023).

Actors Cha Rae-hyung and Lim Ji-yeon were cast together again two years after previously appearing together in SBS's Death's Game (National Death Vote).

Kim Ji-hoon and Oh Yeon-seo were reunited on screen 11 years after previously co-starring in MBC's Wanted, It's Bori.

After casting was announced, there was significant negative reaction to the age gap between lead actor Lee Jung-jae and his co-stars, with industry insiders attributing it to a shortage of leading men in their 20s-30s and a scarcity of suitable actresses close in age who aren't already cast in middle-aged roles.

tvN created an official fan cafe for the show's fictional drama-within-a-drama, 'Good Detective Kang Pil-gu,' which is run almost like a fan cafe for Lim Hyun-joon, with actor Lee Jung-jae posting in character from Hyun-joon's perspective, resembling a form of ARG (alternate reality game) marketing.

A promotional pop-up event called '2025 SKF X Nice to Not Meet You' was held at the Inspire Arena Ballroom.