Nemesis was co-created by Courtney A. Kemp and Tani Marole and was announced by Netflix in March 2025.

Courtney A. Kemp serves as showrunner and executive producer for End of Episode, the production company behind the series.

The first two episodes were directed by Mario Van Peebles, who also serves as an executive producer alongside Tani Marole, Chris Selak and Philipp Barnett.

In April 2025, Sophina Brown, Jeff Pierre and Cedric Joe joined the cast in series regular roles.

In June 2025, Mark Feuerstein joined the cast in a recurring role.

The series was renewed for a second season in June 2026, shortly after its premiere.

On Rotten Tomatoes, season one holds a 78% approval rating based on 18 critic reviews, with critics praising its committed performances and well-executed action sequences.

Metacritic gave the season a score of 70 out of 100 based on 9 critics, indicating 'generally favorable' reviews.