The series finale, a two-part episode titled "The Ultimate Enemy," was dedicated to the memory of series developer, writer, and producer Dwayne McDuffie, who died during the show's production.

Ben 10: Ultimate Alien is the direct sequel to Ben 10: Alien Force and the third series in the Ben 10 franchise, created by the writing team Man of Action and produced by Cartoon Network Studios.

The show introduced the Ultimatrix, a modified version of the Omnitrix that allowed Ben's alien forms to evolve into more powerful "Ultimate" versions.

The series premiered at different times around the world: April 23, 2010 in the US, September 12, 2010 in Canada on Teletoon, and October 10, 2010 in India and Latin America.

A sequel series, Ben 10: Omniverse, premiered in August 2012 following the conclusion of Ultimate Alien.

Like previous entries in the franchise, Ultimate Alien received a tie-in video game released across multiple platforms including Xbox 360, PS2, DS, PSP, Wii, and PS3, along with a spin-off racing game, Ben 10 Galactic Racing.

Bandai produced a toy line for Ben 10: Ultimate Alien, first unveiled at the New York Toy Fair 2010, with the initial wave released in the US in spring 2010 before expanding to Canada and the UK that autumn.

McDonald's ran a promotional tie-in selling six different Ben 10: Ultimate Alien toys with its meals.