The series was the first newly produced animated show to premiere on the PAX network, debuting on 2 October 1999, often airing alongside infomercials.

It was originally planned to air in an hour-long block alongside fellow DIC show Sherlock Holmes in the 22nd Century, but that show ended up airing on Fox Kids instead, so Archie's Weird Mysteries paired with Where on Earth Is Carmen Sandiego? on PAX Kids.

From 2001 onward the series aired in syndication across US stations specifically to help stations comply with mandatory E/I (educational/informational) programming regulations, later becoming part of the syndicated DIC Kids Network block in 2003.

The entire voice cast was provided by the Omaha Theater Company for Young People in Omaha, Nebraska, rather than by typical Hollywood voice actors.

The theme song was written and performed by Mike Piccirillo, who also co-composed the show's musical underscore with Jean-Michel Guirao.

The three-part Riverdale vampires story arc was edited together and released on VHS as its own film, Archie and the Riverdale Vampires, combined with a shortened version of the episode 'Attack of the Killer Spuds' and new narration by Archie, despite containing no newly animated content.

A tie-in ashcan comic was published in 1999, leading to an ongoing regular series starting February 2000 whose first issue served as an origin story explaining the lab incident that made Riverdale a magnet for the supernatural.

The comic tie-in dropped 'Weird' from its title starting with issue #25 as it moved away from the show's premise, doing straight mystery stories without sci-fi or supernatural elements until its cancellation at issue #34.

A sequel TV movie, The Archies in JugMan, was produced as part of DIC's Movie Toons series, reusing much of the same crew and voice cast with updated character designs, and premiered on Nickelodeon on 3 November 2002.