The series was originally developed under the title 'Proof' and had been on TNT's development slate as early as 2009 before receiving a pilot order in September 2010.

Neuroscientist David Eagleman served as the technical consultant on the series, helping ensure accuracy regarding the depiction of the human brain and perception.

Eric McCormack's character was originally named Geoffrey Pierce and later renamed Daniel Pierce before the series went to series.

Rachael Leigh Cook's character was originally announced as Kate Rossi before being renamed Kate Moretti.

Alan Poul directed the pilot and was an executive producer on it, but TNT announced he would not continue as executive producer once the series was picked up.

Although the show is set in Chicago, the pilot was actually filmed in Toronto, Ontario, Canada, before production shifted to Los Angeles, California for the rest of the series.

TNT canceled Perception in November 2014 after three seasons, though the remaining season 3 episodes still aired starting February 17, 2015.