The series was created by José Rivera and Karl Schaefer, with Joe Dante, fresh off the success of the Gremlins films, serving as creative consultant and directing several episodes.

Unlike most television series of its era, Eerie, Indiana was shot on film instead of videotape, which added to its cinematic look.

Halfway through its run, the show was retooled and Jason Marsden's character 'Dash X' was added to the cast.

Archie Hahn's character Mr. Radford was revealed to be an imposter named Fred Suggs, with John Astin brought in to play the 'real' Mr. Radford.

The producers planned an episode called 'The Jolly Rogers', featuring a group of pirates searching for buried treasure in the Teller house, but it was never made.

The final produced episode was a tongue-in-cheek, fourth-wall-breaking story depicting Dash X's attempts to take over as the star of the show.

Despite strong critical reception—with comparisons to Edward Scissorhands, David Lynch, Twin Peaks and The Twilight Zone—NBC canceled the series after only 18 of its 19 produced episodes had aired, likely due to its high production cost.

Gravity Falls creator Alex Hirsch has cited Eerie, Indiana as an influence on his own animated series.