Bob Saget was the producers' first choice for Danny Tanner, but he was unavailable for the pilot due to his contract with CBS' The Morning Program, so actor John Posey played Danny in the unaired pilot, later included on the Season 1 DVD.

John Stamos's character was originally named Jesse Cochran, but producers renamed him Jesse Katsopolis starting in season two at Stamos's request to better reflect his Greek heritage.

Twins Mary-Kate and Ashley Olsen alternated playing Michelle Tanner during tapings and were jointly credited as a single person, 'Mary Kate Ashley Olsen,' from seasons two through seven so audiences wouldn't know the character was played by twins.

Lori Loughlin was originally hired in 1988 for just a six-episode romance storyline with Uncle Jesse but ended up staying with the show until its finale.

Although set in San Francisco, the series was actually taped at Lorimar Studios in Culver City and Warner Bros. Studios in Burbank; the only episode actually filmed on location in San Francisco was the season eight premiere 'Comet's Excellent Adventure.'

A few episodes were shot on location outside the usual studios, including the season three premiere 'Tanner's Island' filmed in Hawaii and the two-part season six finale 'The House Meets the Mouse' filmed at Walt Disney World.

The season 3 episode 'Aftershocks,' in which Stephanie undergoes therapy for earthquake-related anxiety, aired shortly after the real 1989 Loma Prieta earthquake and was intended to help Bay Area children cope with anxiety in its aftermath.

By the time of its cancellation in 1995, despite still ranking in the top 25, ABC cancelled Full House due to rising production costs, which had reached an average of $1.3 million per episode; a planned move to The WB network fell through.