The series often had famous celebrities like Stone Cold Steve Austin, Jay Leno, Charles Barkley, Jerry Springer and Alfonso Ribeiro appear in cameos being protected by Vallery during the first season.

Loni Anderson, who is not related to lead actress Pamela Anderson, guest-starred as Vallery's mother in one episode.

Dustin Nguyen's character Johnny Loh, a karate master and stuntman, started as a recurring role in seasons 1–2 before becoming a main cast member in seasons 3–4.

Angelle Brooks' character Maxine De La Cruz similarly moved from a recurring role in the first two seasons to a main cast credit in seasons 3–4.

The show was co-produced with Poland's Telewizja Polsat, marking the first foreign series that network ever co-created.

A PlayStation video game based on the show was released in November 2001, followed by adaptations for PC, PlayStation 2, Game Boy Color and Game Boy Advance; a planned Xbox version was announced but ultimately cancelled.

In 2000, Johnny Lightning released two sets of V.I.P.-themed diecast cars in 1/64 scale, totaling eight different vehicles.

The series was nominated for a Primetime Emmy Award for Outstanding Main Title Theme Music in 1999, and in 2002 it received three Daytime Emmy nominations, winning for Outstanding Single Camera Editing.