The series was the first show to break the so-called 'Seinfeld curse,' succeeding where other post-Seinfeld projects like The Michael Richards Show, Bob Patterson, Listen Up, and Julia Louis-Dreyfus's own earlier show Watching Ellie had failed.

The series premiere drew an impressive 15.1 million viewers, and the show later received 9 Primetime Emmy Award nominations, with Julia Louis-Dreyfus winning Outstanding Lead Actress in a Comedy Series in 2006.

Production of the third season was halted in November 2007 due to the Writers Guild of America strike, reducing the planned 13-episode season to only 10 episodes.

After CBS canceled the show in 2010, series creator Kari Lizer publicly criticized the network, suggesting the cancellation reflected a lack of support for 'the female-of-a-certain-age point of view' and questioning why CBS would squander the talents of Julia Louis-Dreyfus and Wanda Sykes.

Following the cancellation, Warner Bros. Television, with Lizer's backing, attempted to negotiate moving the series to ABC, but the deal reportedly fell through due to a high licensing fee.

Actress Nancy Lenehan, who later recurred as school principal Mrs. Marcie Nunley starting in season two, had actually guest-starred in season one as a completely different character named Kit.

The German television network adapted the show in 2013 under the title 'Christine. Perfekt war gestern!', but it was canceled after just one season.

All 88 episodes of the series were directed by Andy Ackerman, and filming took place primarily in Los Angeles, California.