The series was originally developed at NBC under the working title 'It's Messy' before being dropped from NBC's slate in January 2012 and then picked up by Fox just days later.

The show was renamed from 'It's Messy' to 'The Mindy Project' on May 11, 2012, only two days after Fox officially ordered the series.

Fox cancelled The Mindy Project after three seasons in May 2015, but Hulu picked it up just over a week later, ordering a 26-episode fourth season.

Stephen Tobolowsky's character, Dr. Marc Shulman, was written out after the second episode following reshoots, as producers decided they didn't want Mindy to have a boss at the office; he later returned only in a voice-over to explain his character's retirement.

Amanda Setton's and Anna Camp's characters were both quietly dropped from the show after the twelfth episode of season one, with their absences never explained or referenced again.

Adam Pally's promotion to series regular in season two came with a built-in condition that his character would leave after the thirteenth episode of season three, though he continued to make guest appearances afterward.

Ike Barinholtz was originally signed only for a recurring role as Morgan Tookers before the character became a regular fixture of the cast.

After the first season, Jezebel published a widely discussed critique titled 'Mindy Kaling Only Makes Out with White Guys,' sparking debate about the show's romantic casting choices.