When broadcast in the United Kingdom starting in late 1967, the show was retitled A Man Called Ironside.

The Old Hall of Justice in San Francisco, whose fourth floor housed Ironside's fictional office, had actually been abandoned by the police in 1961 and was demolished in late 1967 while the series was still in production.

The opening theme, composed by Quincy Jones, was the first synthesizer-based television theme song ever created.

Quincy Jones recorded a fuller four-minute band version of the theme for his 1971 album Smackwater Jack, which was edited down for the opening credits of seasons five through eight; the full track can be heard within the fifth-season episode 'Unreasonable Facsimile'.

The Ironside theme has been sampled numerous times, including in Kill Bill: Volume 1, while Billy Goldenberg's score for the episode 'The Macabre Mr. Micawber' was sampled by hip-hop duo Madvillain for their song 'All Caps'.

For the 1993 TV reunion movie The Return of Ironside, Raymond Burr—who by then was more associated with his role as Perry Mason—had his hair colored and his beard trimmed to a goatee to visually distinguish the two characters, even though it wasn't strictly necessary since he had already been gray-haired during the original series.

During production of the 1993 reunion movie, Raymond Burr was suffering from kidney cancer that had metastasized to his liver, leaving him genuinely unable to stand or walk without assistance, so he did not need to fake using a wheelchair as his character did.

The 2013 remake starring Blair Underwood, relocated to New York City, was cancelled after only four of its nine produced episodes aired due to poor critical and audience reception.