Ben 10: Omniverse was announced at Cartoon Network's Upfront in 2011, and its concept art, unveiled at the 2012 UK Toy Fair, was described as a homage to the original Ben 10 (2005–2008) series.

The series aired across eight 10-episode serialized 'story arcs' rather than following a traditional season-based release structure.

A sneak peek episode aired on August 1, 2012, ahead of the official premiere on September 22, 2012, and an earlier sneak peek was shown after 'Ben 10 Week' in March 2012.

The episode 'T.G.I.S.' reveals that the Ben 10 universe shares continuity with The Secret Saturdays, whose characters like Zak, Doc, and Drew Saturday appear in the voice cast.

Derrick J. Wyatt, previously known for his work on Transformers: Animated and Scooby-Doo! Mystery Incorporated, designed the toys for the series and also served as its art director.

A possible unintentional leak of official toy line images occurred via the website of department store Kmart, revealing figures such as Bloxx, Shocksquatch, and both 11-year-old and 16-year-old versions of Ben before their official reveal.

The 'Rook's Truck' vehicle play set from the toy line won the award for Best Action Figures/Accessories at the 2012 London Toy Fair.

The Omnitrix Touch toy features a gray color scheme, differing from the white version depicted in the show.