Parker and Stone were '95% certain' Al Gore would win the 2000 election and began developing the show under the title Everybody Loves Al before switching the premise to George W. Bush once the contested election was resolved.

The show was originally pitched to Comedy Central under the title Family First and was scheduled to debut on February 28, 2001, but the disputed election results delayed production.

Before landing at Comedy Central, the series concept was pitched to HBO, Fox, NBC, CBS, ABC, FX and MTV, all of which turned it down.

Timothy Bottoms was cast after Parker and Stone spotted his photo in Variety promoting a play he was doing in Santa Barbara, and they immediately felt he was 'perfect' for the role.

Comedy Central prohibited Parker and Stone from depicting the real Bush twins, Jenna and Barbara, so the writers invented the fictional character Princess instead.

Unlike a typical sitcom, That's My Bush! was filmed without a live studio audience so the crew could maintain control and execute shots that wouldn't be possible with an audience present.

The production team was given a private tour of the real White House by a usher, courtesy of executive producer Anne Garefino, allowing them to see rooms not normally open to the public and replicate them accurately as sets.

The episode 'Eenie Meenie Miney Murder' used a live bear, an animatronic bear, an actor in a bear suit, and a puppet bear, which blew the show's budget and contributed to its high cost of about $1 million per episode.

The word 'Lemmiwinks,' intended as a parody of The Lord of the Rings, was first used in the episode 'SDI-Aye-AYE!' before later becoming famous in the South Park episode 'The Death Camp of Tolerance.'

The series finale featured Dick Cheney forcing Bush to step down, complete with an alternate title sequence renamed That's My Dick!, which later changed to What a Dick! within the same episode.

The series premiere set a Comedy Central ratings record at the time with over 2.9 million viewers, though the average viewership later dropped to about 1.7 million.

Making That's My Bush! led Parker and Stone to adopt a three-act story structure, which they found more effective and subsequently carried over to South Park, replacing its previous four-act format.