The series is based on Steve Dildarian's animated short 'Angry Unpaid Hooker,' which won the Best Animated Short award at the 2006 Comedy Arts Festival in Aspen.

The show was originally developed for Fox in 2007 before being picked up by HBO for a 10-episode order.

The Life & Times of Tim was the first HBO original animated series since Todd McFarlane's Spawn, which aired from 1997 to 1999.

Series creator Steve Dildarian, previously known for the 'Budweiser Lizards' ad campaign, both created the show and voiced the lead character Tim.

Alan Tudyk took over the role of Debbie the Prostitute starting in season 3, a character previously voiced by Bob Morrow.

The show featured numerous celebrity guest voices playing themselves or comedic characters, including Bob Saget, Bob Einstein, Jeff Garlin, Cheri Oteri, Daniel Tosh, Elliott Gould, Bob Odenkirk, Billy Dee Williams, and Tim Meadows.

The show's theme song is 'I'll Never Get Out of This World Alive,' performed by country music legend Hank Williams.

HBO cancelled the series in June 2010 after season two, but reversed the decision in August 2010 and ordered a third season following rumors it might be picked up by another network.