The series was developed under the working title 'Man from the Stars' and writer Park Ji-eun based the story on the Gwanghae Journal from the Annals of the Joseon Dynasty, which documents sightings of unidentified flying objects resembling halos or washbowls across Gangwon Province on August 25, 1609 (September 22 by the solar calendar).

Park Hae-jin was originally cast to play the villain Lee Jae-kyung while Choi Min was set to play Lee Hee-kyung, but after Choi Min was injured, Park's role was changed to Lee Hee-kyung and Shin Sung-rok was brought in to play Lee Jae-kyung instead.

Actor Yunho of TVXQ was also considered for the role of Lee Hee-kyung at one point but had to withdraw due to scheduling conflicts.

The drama marked the second on-screen collaboration between Kim Soo-hyun and Jun Ji-hyun, following their hit film The Thieves (2012), and represented Jun Ji-hyun's return to television after 14 years.

Filming began in early November 2013 after the first script reading was held on October 14, 2013.

To depict Do Min-joon's time-stopping and teleportation superpowers, the production crew used 60 small special cameras arranged in a 180-degree arc, including GoPro cameras, to create bullet-time effects by filming 'stopped' characters from multiple angles.

My Love from the Star was the first Korean television drama to be produced using high-definition cameras.

Although originally planned as a 20-episode series, the production company added an extra episode due to strong viewer demand, extending the final run to 21 episodes.

Throughout the series, the male lead repeatedly quotes from Kate DiCamillo's children's novel The Miraculous Journey of Edward Tulane, which subsequently topped bestseller lists in major Korean bookshops after the drama aired.

The show sparked a huge craze in China for 'chimaek' (fried chicken and beer) after a famous scene, and Korean instant noodle maker Nongshim reported record sales in China during the drama's broadcast period due to a noodle-eating scene.

Because Chinese censorship restricts depictions of aliens and supernatural beings, the version aired on Chinese channel Anhui ended differently, reframing the entire story as a fictional tale written by Do Min-joon for Cheon Song-yi.

The series became so popular in China that it was reportedly discussed at China's National People's Congress in March 2014, topping the agenda of a cultural and entertainment committee delegation.

A Chinese production company re-edited the series into a two-hour feature film released in theaters in August 2014 due to its popularity in mainland China.

An American remake was announced in September 2014 to be developed at ABC with writers Elizabeth Craft and Sarah Fain, but it was later shelved for undisclosed reasons.

Author Kang Kyung-ok accused the drama of plagiarizing her 2008 comic book Seol-hee shortly after the show premiered; she filed a ₩600 million lawsuit in 2014 but dropped it after an out-of-court settlement in July 2014.

An Indonesian network aired an unauthorized, plagiarized version of the series titled Kau Yang Berasal Dari Bintang in April 2014, which used the exact same plot and setup as the Korean original.