The series was originally going to be titled 'Mosquita muerta', but Antena 3 changed it to Vis a Vis before its premiere, and the original title was never used officially (though it appears as the first episode's title on Netflix).

The first season was originally planned to have 13 episodes, but due to overlap between filming and broadcast, only eleven episodes were ultimately produced.

When the series was announced, some media outlets compared it to the American show Orange Is the New Black, calling it a mere copy, but after the pilot aired, critics acknowledged its differences from the Netflix series.

The prison set was built in an industrial estate in Colmenar Viejo, Madrid; for the third and fourth seasons production moved to a different location, and the original studio was reused as the set for another Álex Pina show, Money Heist.

Maggie Civantos' role as Macarena was reduced starting with season 3 due to her commitments to another show, shifting the series to a full ensemble format.

After being cancelled by Antena 3 following season two, the series was picked up just over a year later by Fox Spain, which co-produced its first fictional series in Spain with seasons 3 and 4; season 3 became the most-watched premium TV program in its timeslot in Spain.

Rotten Tomatoes reported a 100% approval rating for the second season based on 11 critic reviews, with an average score of 8.0/10.

Before the premiere of season 3, Fox broadcast a prequel short film titled 'Yo Soy Zulema', narrated by the character Zulema and featuring three versions of her at different ages.

The show's universe was expanded with a spin-off film, Vis a vis: El Oasis (2020), serving as the fifth and final season, and with a Spanish audio series, Vis a Vis: La Cara B, released on Audible in 2020, set after season four and featuring Maggie Civantos and Najwa Nimri reprising their roles.