Clayne Crawford, who played Martin Riggs for two seasons, was fired from the show in May 2018 following reports of hostility and behavioral issues on set, leading to his character being killed off.

Seann William Scott was hired to replace Clayne Crawford for season three, playing an entirely new character named Wesley Cole rather than taking over the Riggs role.

Damon Wayans left the series after season three production ended in December 2018, citing health problems; he later revealed he is diabetic.

Fox Entertainment CEO Charlie Collier stated in February 2019 that there was a strong possibility Damon Wayans could return if the series was renewed for a fourth season.

After Damon Wayans revealed his diabetes, producers rearranged his shooting schedule and provided diabetic meals for him on set.

Keesha Sharp took over the role of Trish Murtaugh after Golden Brooks originally played the character before the series moved forward.

The character Wesley Cole, introduced in season three, is based on a combination of two film characters: Lorna Cole (played by Rene Russo) and Lee Butters (played by Chris Rock).

Several TV series characters are directly modeled on film counterparts, such as Leo Getz (based on Joe Pesci's character), Captain Brooks Avery (based on Steve Kahan's Captain Ed Murphy), and Riana and RJ Murtaugh (based on Rianne and Nick Murtaugh from the films).

The show's critical reception improved dramatically over its run: season one held a 67% approval rating on Rotten Tomatoes, while seasons two and three both achieved 100% approval ratings from critics.