Re:Creators was created and written by Rei Hiroe, the manga artist known for creating Black Lagoon, who also provided the original character designs, while Ei Aoki directed the series.

Hiroe's original story for the anime was also published as a text serialization on Shogakukan's Sunday Webry website under the title Re:Creators Naked.

Character designer Ryuichi Makino noted that Rui Kanoya was modeled on Shinji Ikari from Neon Genesis Evangelion, combining traits from various robot anime protagonists; early designs even included a pilot helmet for him that was later dropped.

For the villain Altair, the design was fixed on a military uniform from the start; the character was initially given an old German-style helmet before settling on a Russian cavalry hat.

Magane Chikujōin's design was altered during development because her hairstyle initially resembled Shenhua from the manga Black Lagoon, also created by Rei Hiroe, so alternative hairstyles were considered.

Yūya Mirokuji's character design originally featured a camouflage jacket and a neck tattoo in the original character sheets, but these were cut in the anime adaptation in favor of giving him a hunched posture.

The series' music was composed by Hiroyuki Sawano, and the villain Altair's ending theme for episode 13, 'World Étude,' was performed in-universe by her own voice actress Aki Toyosaki under the character's name.

The production deliberately did not use the full runtime of its two-cour, 22-episode format for straightforward story episodes; instead, the leftover time was filled with three special programs featuring cast interviews and segments with the characters.

The character Hangaku, a female armored warrior spirit summoned by Mirokuji, is based on the historical female warrior Hangaku Gozen.

An in-universe memorial event called 'Kirameki Mamika Farewell Gathering' was actually held for fans at the Akiba CO Gallery on June 10-11, 2017, blurring the line between the fictional character's story and real-world promotion.