The series is based on a four-part graphic novel of the same name created by writer Grant Morrison and artist Darick Robertson.

Brian Taylor served as director for a majority of the episodes, directing seven of the first eleven episodes.

In the pilot, the imaginary unicorn Happy was originally voiced by Bobby Moynihan before being replaced by Patton Oswalt for the series.

Christopher Meloni, who plays lead character Nick Sax, also has a guest role voicing/playing Janet Sax, Nick's mother, in the episode 'Pervapalooza'.

Actor Ritchie Coster plays a dual role, portraying both crime boss Francisco 'Mr. Blue' Scaramucci and Orcus, the Roman god of death who possesses Scaramucci's body.

The series features notable guest appearances including Jerry Springer playing himself, 'Weird Al' Yankovic voicing Smoking Man Baby, and Jeff Goldblum playing God in the episode 'Resurrection'.

Rotten Tomatoes gave the series an approval rating of 81% based on 36 reviews, while Metacritic assigned a score of 65 out of 100 based on 21 reviews, indicating generally favorable reviews.

After being renewed for a second season on January 29, 2018, which premiered March 27, 2019, the series was ultimately cancelled by Syfy on June 4, 2019 after two seasons.