Unlike the original series which was filmed in the New York area, the reboot has moved production city to city each season, filming in Atlanta, Kansas City, Philadelphia, Austin, and New Orleans over its run.

An episode was filmed in the small Australian town of Yass, New South Wales, which was chosen specifically because its name matches the cast's favorite exclamation, 'yaass'.

Interior design expert Bobby Berk left the show after season 8, and was replaced for season 9 by Jeremiah Brent.

Creator David Collins has expressed interest in filming a season in the Midwest tristate region of Ohio, Indiana, and Kentucky, since he was born and raised in Cincinnati, Ohio.

Season 2 introduced a new theme song performed by singer Betty Who.

The Fab Five voiced fictionalized versions of themselves in a 2019 episode of the adult animated series Big Mouth.

The cast appeared as animated cartoon characters alongside Lizzo in her 'Soulmate' music video, released in celebration of Pride month in June 2020.

After Taylor Swift's 'You Need to Calm Down' music video (featuring the cast) drew criticism for alleged performative allyship, Tan France publicly defended Swift, calling her a 'powerful ally' to the LGBTQ+ community.