Good Trouble was developed as a spin-off of Freeform's The Fosters, launched after that series' ending was announced, following Callie and Mariana Adams Foster living in Los Angeles five years after the parent show's finale.

The series was initially given a 13-episode order for its first season.

On December 10, 2018, it was reported that the California Film Commission had approved $6.6 million in tax credits for a potential second season, ahead of Freeform's official renewal decision.

Maia Mitchell stepped down from her role as Callie and from her position as executive producer in order to be with her family in Australia, with her final main cast appearance in the second episode of season four before returning as a guest star in season five.

Several actors were promoted or recast over the show's run, including Priscilla Quintana being upgraded to series regular and Yasmine Aker being cast to replace Odelya Halevi in a recasting for season four.

Bryan Craig and Booboo Stewart joined the cast for season four, with Craig becoming a series regular and Stewart in a recurring capacity before being promoted to regular in season five.

The series holds a 100% approval rating on Rotten Tomatoes based on 13 reviews, with an average rating of 8.93/10, and a Metacritic score of 83 out of 100 indicating 'universal acclaim'.

The show received three Teen Choice Award nominations and two GLAAD Media Award nominations during its run.