The series was originally titled Here Comes the Neighborhood during its pilot production commitment in 2017, then changed to Welcome to the Neighborhood upon receiving a series order, before finally being renamed The Neighborhood just days later.

Creator Jim Reynolds stepped down as showrunner and executive producer after three seasons in April 2021 following complaints about his 'insensitive comments and other race-related issues' over time, leading to a succession of showrunner changes including Meg DeLoatch and later Bill Martin and Mike Schiff.

Josh Lawson was originally cast as Dave Johnson and Dreama Walker as Gemma Johnson during the pilot stage, but both were replaced before the series aired by Max Greenfield and Beth Behrs respectively.

James Burrows, a veteran sitcom director, was announced to direct the pilot episode in February 2018.

Although the show is set in Pasadena, California, it was actually filmed at Radford Studio Center in Studio City, California.

Actor Garrett Morris, who played Jasper in a season 7 guest role, previously worked with co-star Beth Behrs on the sitcom 2 Broke Girls (2011–17).

The season 7 finale, depicting Malcolm and Marty moving from Pasadena to Venice Beach, was intended as a possible backdoor pilot for a spin-off focused on the two brothers; the spin-off was ultimately not picked up by CBS.

A spin-off titled Crutch, introducing Tracy Morgan as Calvin's cousin Francois 'Crutch' Crutchfield, was picked up by Paramount+ and had all eight episodes released on November 3, 2025.

The first season received a mixed-to-negative critical response, holding just a 24% approval rating on Rotten Tomatoes based on 17 reviews, with critics citing poor character writing and mishandling of social commentary.