Alex Garland created, wrote, and directed every episode of the miniseries himself.

FX initially ordered only a pilot in March 2018, but by August 2018 the network bypassed the pilot process entirely and gave the show a straight-to-series order of eight episodes.

Garland said the series grew out of his fascination with reading about science, particularly the philosophical principle of determinism and its implications for free will.

The show was originally set to air on FX but was switched to premiere on Hulu under the 'FX on Hulu' banner, announced in November 2019.

Rob Hardy served as the cinematographer for the series, a role he confirmed in a July 2018 interview.

Filming took place at UC Santa Cruz, among other locations, starting around August 2018.

Amaya Mizuno-André, who plays Forest's young daughter Amaya, is the real-life niece of lead actress Sonoya Mizuno.

Theoretical physicist Sean Carroll was interviewed by The New York Times about the show's sweeping statements on determinism, and he praised Devs as a well-done, slow and contemplative departure from typical action-driven sci-fi.