Filming for the third and final season began on May 7, 2021, but was temporarily paused in August 2021 due to Christina Applegate's health issues.

Production of season three faced further delays, including positive COVID-19 cases on set in December 2021, and filming did not wrap until April 25, 2022, well after the initially planned early 2022 completion.

The series was created by Liz Feldman, who wrote for the show and executive produced it alongside Will Ferrell, Adam McKay, and Jessica Elbaum, with production companies Gloria Sanchez Productions and CBS Television Studios involved.

The third season's production was significantly delayed due to Christina Applegate's multiple sclerosis diagnosis, pushing the final season's release to November 2022, over two years after season two.

James Marsden played dual roles across the series, portraying both Steve Wood in season one and his semi-identical twin brother Ben Wood in seasons two and three.

Christina Applegate was cast in one of the two lead roles in July 2018, with Linda Cardellini joining as the other lead the following month in August 2018.

Netflix announced in July 2019 that Dead to Me was on track to be streamed by over 30 million viewers within its first month of release.

Christina Applegate received three consecutive Primetime Emmy Award nominations for Outstanding Lead Actress in a Comedy Series for her role, spanning the 71st, 72nd, and 75th Emmy Awards.