Lovecraft Country is based on and serves as a continuation of Matt Ruff's 2016 novel of the same name, developed for television by Misha Green.

Jordan Peele originally brought the project to Bad Robot and enlisted Misha Green to develop the show, with Peele, J.J. Abrams and Ben Stephenson serving as executive producers alongside Green, who also wrote the pilot.

Elizabeth Debicki was originally cast as Christina Braithwhite in June 2018, but she was replaced by Abbey Lee in June 2019.

Michael Kenneth Williams was cast in a leading role as Montrose Freeman, Atticus's father.

Principal photography began on July 16, 2018, in Chicago, Illinois, with additional filming at Chicago Cinespace Film Studios in Elburn, Illinois, White Pines State Park in Mount Morris, Illinois, and Blackhall Studios in Atlanta and Macon, Georgia.

Composer Laura Karpman and her team had to score the series remotely from Eastern Europe due to COVID-19 pandemic restrictions, with Karpman personally recording piano and keyboard tracks since she could not have direct interaction with musicians.

The series holds an 88% approval rating on Rotten Tomatoes based on 367 reviews and a weighted average score of 79/100 on Metacritic, indicating generally favorable reviews.

In James Andrew Miller's book Tinderbox: HBO's Ruthless Pursuit of New Frontiers, several writers on the show alleged that its cancellation after one season was due to Misha Green creating a hostile work environment.

Critic Maya Phillips of The New York Times criticized the show for using real historical events like the funeral of Emmett Till and the Tulsa race massacre merely to gain relevance rather than meaningfully engaging with them.