Warner Bros. and CBS Films first tried to adapt The Stand as a feature film starting in 2011, going through directors David Yates, Ben Affleck, and Scott Cooper before the project stalled, with each eventually leaving due to difficulty condensing King's sprawling novel.

Director Josh Boone originally planned to split his adaptation into four full-length feature films, and Warner Bros. even proposed an eight-part Showtime miniseries to set up the story before it would culminate in Boone's films, but the project was put on hold in 2016 and rights reverted to CBS Films.

Josh Boone, who was set to write and direct an earlier film version, revealed he had wanted Christian Bale to play Randall Flagg and Matthew McConaughey to play Stu Redman.

The miniseries features an entirely new ending for its final episode, co-written by Stephen King with his son Owen King, expanding on the 1990 uncut edition's ending and making it the third variation of the story's conclusion.

Musician Marilyn Manson was originally cast in an undisclosed role and even recorded a cover of The Doors' 'The End' with Shooter Jennings for the series, but his part as The Kid was ultimately cut from the script and the song could not be used due to the show's tight budget.

Casting hearing actor Henry Zaga as the deaf character Nick Andros sparked backlash from deaf actors; director Josh Boone defended the choice by explaining that the character can hear and speak in his dreams and as a ghost, and noted Zaga was learning ASL with deaf consultants on set.

Several characters were gender-swapped for the adaptation, including The Rat Man (played by Fiona Dourif) and Ralph Brentner, renamed and played by Irene Bedard.

The series includes cameo appearances from Mick Garris, director of the 1994 miniseries adaptation, as well as Stephen King himself, while Bryan Cranston provided a voice-only cameo as the President of the United States.

Filming took place in and around Vancouver, British Columbia from September 2019 to March 2020 under the working title 'Radio Nowhere,' using locations like Ladner Trunk Road and Port Coquitlam to stand in for Boulder, Colorado.

Production wrapped just a few days before it would have been forced to shut down due to the COVID-19 pandemic.

The original score was composed by Nate Walcott and Mike Mogis, longtime collaborators of director Josh Boone on his earlier films Stuck in Love and The Fault in Our Stars.

The miniseries received mixed reviews, holding a 57% approval rating on Rotten Tomatoes and a Metacritic score of 56/100, with critics praising the cast and dark tone but criticizing its lengthy runtime and slow pacing.