The series was written by the Hong sisters and directed by Oh Chung-hwan, produced by GTist, and aired on tvN from July 13 to September 1, 2019.

The hotel's owner Jang Man-wol was played as an adult by Lee Ji-eun (IU) and as a child by Kim Gyu-ri, while manager Gu Chan-sung was played by Yeo Jin-goo as an adult and Kim Kang-hoon as a child.

Actress Sulli made a special appearance in the series as the character Jung Ji-eun, one of her final on-screen roles before her death.

Actor Kim Soo-hyun appeared in a special cameo as the new owner of the Guest House of the Moon, which is renamed 'Hotel Blue Moon' at the end of the series.

The character Deity Magu, who oversees life and death, was portrayed by a single actress, Seo Yi-sook, playing twelve different sister-like personas of the same goddess.

On June 24, 2020, Studio Dragon announced it would co-produce an American remake of Hotel del Luna with Skydance Television, with Alison Schapker developing and producing the new version.

On January 27, 2021, theater company Showplay announced that Hotel del Luna would be adapted into a stage musical, which premiered in South Korea in 2022.