The series is a direct sequel to Cult of Chucky (2017), continuing the cliffhanger where Chucky's soul transfers into a female body, putting the character on a path of sexual exploration.

Creator Don Mancini took a semi-autobiographical approach with Jake Wheeler, a gay teenager whose father struggles to accept his sexuality, drawing on Mancini's own adolescence.

While developing the show, Mancini worried that a successful 2019 Child's Play reboot (made without his approval) could have led Universal to abandon the original film continuity, though ultimately it did not affect the series.

Fiona Dourif plays an adult version of Charles Lee Ray, but her voice was replaced with Brad Dourif's in post-production because Nica sounding too similar to Charles would have confused audiences.

Don Mancini cast non-binary actor Lachlan Watson as both Glen and Glenda after meeting them at a virtual San Diego Comic-Con panel about transgender representation.

WWE wrestler Liv Morgan, a self-declared lifelong Child's Play fan, was written into the season 2 episode 'Death on Denial' at her own request.

It took a team of six or seven puppeteers to operate Chucky, accounting for about 99.5% of the doll's on-screen actions, with digital effects used only to erase puppeteers, rods, or cables.

Multiple physical Chucky props were used simultaneously on set for different purposes, such as one for rough movement and another with functioning mouth animatronics for close-ups, making scenes with doll-actor interaction significantly longer to shoot.

Filming of season 3 was interrupted by the 2023 SAG-AFTRA strike, forcing the season to be split into two halves, with the crew rushing to complete the first four episodes before the hiatus.

Composer Joseph LoDuca used a detuned toy piano in season 1 to symbolize Chucky's feigned innocence, while piano chords represented Jake and Devon's relationship.

A promotional teaser had Chucky reenact the trailer for the 1978 film Magic while performing his classic voodoo chant to Damballa.