The series was created by RZA and Alex Tse, who portray a fictionalized account of the formation of the Wu-Tang Clan set in New York City during the early 1990s crack epidemic.

Hulu gave the production a series order of ten episodes on October 11, 2018, with RZA and Alex Tse writing and executive producing alongside Brian Grazer, Merrin Dungey, and Method Man.

Real Wu-Tang Clan members Ghostface Killah, Inspectah Deck, Masta Killa, and GZA, along with the estate of Ol' Dirty Bastard, served as consulting producers on the show.

The role of Jason 'Inspectah Deck' Hunter was played by Joey Bada$$ in season 1, then recast with Uyoata Udi for seasons 2 and 3.

Principal photography began in February 2019 in New York City, with additional filming in several New Jersey locations including East Orange, Elmwood Park, Kearny, Newark, Paterson, Plainfield, and Secaucus.

The first season holds a 74% approval rating on Rotten Tomatoes based on 19 reviews and a Metacritic score of 58/100, indicating 'mixed or average' reviews.

According to Parrot Analytics, Wu-Tang: An American Saga was the 10th most in-demand streaming series in the United States during the week of September 11 to 17, 2021.

The series was released internationally on Disney+ through the Star hub in selected territories.