The series is a direct sequel to the 1983–1985 He-Man and the Masters of the Universe series, deliberately ignoring the events of She-Ra: Princess of Power (1985–1987) and The New Adventures of He-Man (1990).

Kevin Smith officially announced the project at the Power-Con convention in 2019, saying he wanted to tell a story set in Eternia that resolved lingering plot threads from the original series while functioning as if it were simply the next episode of the 1983 show.

Netflix originally announced two separate Masters of the Universe projects in December 2019: an adult-oriented anime-style direct sequel series and a separate CGI series aimed at children.

ND Stevenson, creator of She-Ra and the Princesses of Power, expressed interest in a potential crossover Christmas special between the two shows, despite Revelation being a sequel to the original non-DreamWorks cartoon rather than the Stevenson reboot.

Melissa Benoist replaced Sarah Michelle Gellar as the voice of Teela for the sequel series Masters of the Universe: Revolution.

Meg Foster, who played Evil-Lyn in the 1987 live-action Masters of the Universe film, returned to the franchise decades later to voice a new character, Motherboard, in Revolution.

Weeks before Revolution's release, it was revealed that Gates McFadden would replace Alicia Silverstone as the voice of Marlena, while John de Lancie joined the cast to voice Granamyr.

Powerhouse Animation Studios, which took inspiration from Japanese anime for its visual style, provided the animation for the series, with additional animation services from DR Movie.