Senhora Secretária

The series was partially inspired by Hillary Clinton's experiences as U.S. Secretary of State.

Filming took place mainly in New York, with some exterior scenes filmed in Washington D.C.

Bebe Neuwirth left the series after the third episode of the fourth season, being replaced by Sara Ramirez in the role of Kat Sandoval as a regular cast member.

For the sixth and final season, several regular actors (including Sara Ramirez, Geoffrey Arend, Evan Roe, Kathrine Herzer, Keith Carradine, and Sebastian Arcelus) were removed from the main cast, while Kevin Rahm, who had been recurring until then, was promoted to regular.

Three former U.S. Secretaries of State — Hillary Clinton, Madeleine Albright, and Colin Powell — were avowed fans of the series and even made a special appearance together at the premiere of the fifth season, which aired on October 7, 2018.

The series is particularly popular in Finland, where 9% of the population watched the premiere episode when it aired on MTV3 on January 1, 2015.

The trailer for the 'Break in Diplomacy' episode from the third season generated controversy in the Philippines by showing the protagonist punching a fictional Filipino president that viewers associated with President Rodrigo Duterte, leading the Philippine Embassy to publish an official protest.

The premiere of the fourth season, 'News Cycle', provoked protest from Timorese Minister José Ramos-Horta, Nobel Peace Prize recipient, for depicting East Timor as a narco-state controlled by a Mexican drug cartel.

In the fourth episode of the first season, the series used archival footage filmed in Hoi An, Vietnam, but incorrectly identified the location as Fuling, China, which angered the Vietnamese government and resulted in the series being banned in Vietnam, including removal from local Netflix.